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BIBTEX RIS

Tobacco smoke‐induced left ventricular remodelling is not associated with metalloproteinase‐2 or ‐9 activation

2007; Elsevier BV; Volume: 9; Issue: 11 Linguagem: Inglês

10.1016/j.ejheart.2007.09.004

1879-0844

Édson Castardeli, Daniella R. Duarte, Marcos Ferreira Minicucci, Paula S. Azevedo, Beatriz B. Matsubara, Luiz Shiguero Matsubara, Álvaro Oscar Campana, Sérgio Alberto Rupp de Paiva, Leonardo A. M. Zornoff,

Cardiovascular Effects of Exercise

Abstract Aim To investigate the role of MMP‐2 and MMP‐9 in cardiac remodelling induced by tobacco smoke exposure in rats. Methods Rats were allocated into two groups: C ( n =9): control animals; ETS ( n =9): exposed to tobacco smoke. After 4months, the animals underwent echocardiography, morphometric study and determination of MMP‐2 and MMP‐9 activity. Results ETS rats had larger diastolic ( C =15.6 ±1.2mm/kg, ETS=18.0±0.9mm/kg; p < 0.001) and systolic ( C =7.3±1.2mm/kg, ETS=9.2±0.9mm/kg; p =0.001) ventricular diameters adjusted for body weight. Fractional shortening ( C 53–4.8%, ETS+48±3.3%; p =0.031) and ejection fraction ( C =0.89±0.03, ETS=0.86±0.02; p =0.030) were smaller in the ETS group. Myocyte cross‐sectional area ( C =245±8μm 2 , ETS=253±8μm 2 ; p =0.028) was higher in ETS rats. There were no differences in MMP‐2 ( C =50±14%; ETS=43±11%, p =0.228) or MMP‐9 ( C =0.36±0.3%; ETS=0.62±0.3%, p =0.630) activity between the groups. Conclusion MMP‐2 and MMP‐9 did not participate in the remodelling process induced by tobacco smoke exposure.