Portal de Periódicos da CAPES

N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

1993; Elsevier BV; Volume: 3; Issue: 11 Linguagem: Inglês

10.1016/s0960-894x(01)80982-3

1464-3405

Iwao Ojima, Martine Zucco, Olivier Duclos, Scott D. Kuduk, Chung Ming Sun, Young Hoon Park,

Synthetic Organic Chemistry Methods

(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.