Intrinsic Versus Extrinsic Vascularization in Tissue Engineering
2007; Mary Ann Liebert, Inc.; Linguagem: Inglês
10.1007/978-0-387-34133-0_21
ISSN1557-8690
AutoresElias Polykandriotis, Raymund E. Horch, Andreas Arkudas, Apostolos P. Labanaris, Kay Brune, Peter Greil, Alexander D. Bach, Jürgen Kopp, Andreas Heß, Ulrich Kneser,
Tópico(s)Tissue Engineering and Regenerative Medicine
ResumoIn-vitro culture of tissues can be regulated by controlled medium administration whereas ex-vivo bioreactors are designed with the capability of providing tissue engineered devices with continuous nutrient support. When these materials or cellular constructs are transferred in vivo they have to rely on processes like interstitial fluid diffusion and blood perfusion. Here recites a core limitation for transfer of tissue engineering models from the in vitro to the in vivo environment. Diffusion is the initial process involved but it can only provide for cell support within a maximum range of 200 μm into the matrix., , ,
Referência(s)