Portal de Periódicos da CAPES

Immunomodulatory and anti-SARS activities of Houttuynia cordata

2008; Elsevier BV; Volume: 118; Issue: 1 Linguagem: Inglês

10.1016/j.jep.2008.03.018

1872-7573

Kit-Man Lau, Kin-Ming Lee, Chi Man Koon, Crystal Sao‐Fong Cheung, Ching-Po Lau, Hei-Ming Ho, Mavis Yuk-Ha Lee, Shannon Wing-Ngor Au, Christopher H.K. Cheng, Clara Bik‐San Lau, Stephen Kwok‐Wing Tsui, David Chi‐Cheong Wan, Mary Miu Yee Waye, Kam‐Bo Wong, Chun-Kwok Wong, Christopher Wai‐Kei Lam, Ping-Chung Leung, Kwok‐Pui Fung,

Phenothiazines and Benzothiazines Synthesis and Activities

Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4+ and CD8+ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg. The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.