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The 45th Anniversary of the American Pancreatic Association and the Japan Pancreas Society

2014; Lippincott Williams & Wilkins; Volume: 43; Issue: 8 Linguagem: Inglês

10.1097/mpa.0000000000000235

1536-4828

Vay Liang W. Go, Jennifer B. Carney, Erin A. Brudvik,

Pancreatitis Pathology and Treatment

This is the second joint meeting of the American Pancreatic Association (APA) and the Japan Pancreas Society, celebrating our 45-year histories in Kohala Coast, Hawaii. Both societies were founded to foster research advances in pancreatic function and disease.1,2 The previous joint meeting took place in Honolulu, Hawaii, in 2009 to celebrate the 40th anniversaries of the 2 societies.3 The 2 societies have both grown from pancreatic study groups into leading national societies for the advancement of research into pancreatic biology and diseases. The societies have worked closely together, fostering interaction and collaboration between researchers in Japan and the United States. The ongoing relationship between the 2 societies continues to provide invaluable opportunities for the international study of pancreatic diseases and has provided significant advancement of knowledge in the global village of basic pancreatic biology in the management of pancreatic diseases. We congratulate both societies on their 45th anniversaries. This year marks the inaugural Paul D. Webster III Lectureship for the American Pancreatic Society. The lecture will be delivered by Dr Andrew L. Warshaw, W. Gerald Austen Professor of Surgery at Harvard Medical School, on November 7. The lectureship is named in honor of Dr Paul D. Webster III, who cofounded the APA along with Drs Vay Liang Go and Frank Brooks.1 The annual APA meeting provides a forum for presentations, discussion, and interaction among key investigators including clinicians and basic scientists in pancreatology. The meeting also focuses on providing mentorship to new and young investigators. In addition, the society also honors individuals who have made great scientific contributions throughout their careers with the Vay Liang and Frisca Go Award for Lifetime Achievement. This is the highest honor bestowed by the APA to members of our society. The society also honors individuals who help fulfill the APA mission to advance clinical and basic pancreatic research with the APA Distinguished Service Award. In addition, the APA recognizes the contributions of up and coming researchers by presenting travel awards and awards sponsored by the National Pancreas Foundation and Hirshberg Foundation for outstanding abstracts in pancreatitis and pancreatic cancer, respectively. 2014 VAY LIANG AND FRISCA GO AWARD FOR LIFETIME ACHIEVEMENT In 2001, the board of the APA established the Vay Liang and Frisca Go Award for Lifetime Achievement to honor those who have made great scientific contributions to the field of pancreatology. This year's awardees are Dr Ashok Saluja, professor and vice chair of the Department of Surgery of the University of Minnesota and current APA secretary-treasurer, and Dr William Y. Chey, professor emeritus of the University of Rochester and director of the Rochester Institute for Digestive Diseases and Sciences. They join a growing list of honorees (Fig. 1), which includes Drs Micheal Steer and Masao Tanaka (2013); Drs Horst F. Kern and Murray Korc (2012); Dr Andrew L. Warshaw (2011); Dr Peter A. Banks (2010); Drs Katsusuke Satake and Fred Gorelick (2009); Dr Daniel S. Longnecker (2008); Dr Howard A. Reber (2007); Drs Tadashi Takeuchi and Phillip P. Toskes (2006); Dr John A. Williams (2005); Dr Paul D. Webster (2004); Dr James D. Jamieson (2003); Dr Eugene P. DiMagno (2002); and Dr Vay Liang W. Go (2001).4,5FIGURE 1: American Pancreatic Association Vay Liang and Frisca Go Award for Lifetime Achievement recipients: (starting at top, left to right) Murray Korc, MD, Horst F. Kern, MD, Andrew L. Warshaw, MD, Peter A. Banks, MD, Katsusuke Satake, MD, Fred S. Gorelick, MD, Daniel S. Longnecker, MD, Howard A. Reber, MD, Philip P. Toskes, MD, Tadashi Takeuchi, MD, PhD, John A. Williams, MD, PhD, Paul D. Webster, III, MD, James D. Jamieson, MD, PhD, Eugene P. DiMagno, MD, Vay Liang W. Go, MD, Ashok Saluja, PhD, William Y. Chey, MD.Ashok K. Saluja, PhDFigureDr Ashok Saluja obtained his BSc (Hons) and MSc (Hons) in biochemistry in Punjab, India, before moving to the United States where he obtained his doctoral degree in biochemistry from Washington State University in 1980. After a postdoctoral stint at Cornell University, he joined Harvard Medical School where he rose to the rank of associate professor in surgery. It was here that he began his pancreatic research while working with long-time collaborator, Dr Michael Steer. After 20 years at Harvard Medical School, he joined the University of Massachusetts Medical School as Professor of Surgery, Medicine, and Cell Biology and as Director of the Pancreatic Diseases Center. In 2006, Dr Saluja joined the faculty of the Department of Surgery and Medicine at the University of Minnesota Medical School as professor and vice chair. He also holds the Sit Family Chair in Pancreatic and Gastrointestinal Cancer Research as well as the University of Minnesota McKnight Presidential Endowed Chair. He also serves as Associate Director of Experimental Therapeutics at the Masonic Cancer Center. Dr Saluja's research focuses on understanding the physiology of the pancreas and the pathophysiology of pancreatic diseases. He is internationally renowned for his work on the pathogenesis of pancreatitis. His group has shown that pancreatic tumors overexpress heat shock protein 70 and that its inhibition causes death of these cells not only in in vitro settings but also in mouse models of pancreatic cancer. In collaboration with Dr Selwyn Vickers, Dr Saluja's group has been successful in developing a small molecule, which they have named Minnelide™. This compound is very efficacious in several models of pancreatic cancer. This novel drug entered phase 1 clinical trials in fall of 2013 and participants are currently being actively recruited. This is the first time in University of Minnesota history in which a small-molecule drug invented in a research lab has been taken to clinical trial in any form of cancer. In other studies, Dr Saluja is evaluating novel strategies in combination with Minnelide™ to treat otherwise nonresponsive and very aggressive pancreatic tumors. His group is also evaluating the efficacy of Minnelide™ in other solid tumors. Dr Saluja has published more than 120 original research articles in peer-reviewed international journals along with several review articles and book chapters. His research has been funded by the National Institutes of Health (NIH) and several biotechnology companies in addition to philanthropic support. In addition, he is an inventor on 2 patents. He is one of the largest NIH-funded investigators at the University. He is also a Chief Scientific Officer and cofounder of a start-up biotechnology company in the oncology arena. For years, Dr Saluja has been invited to give numerous state-of-the art lectures and keynote addresses at national and international meetings. He has served on numerous NIH panels and editorial boards of several scientific journals. He has mentored over 60 basic and clinical scientists for 3 decades of his academic career, many of whom have gone on to high academic positions and continue to be active in pancreas research. Dr Saluja is a past President of the APA and he is currently the Secretary-Treasurer of the APA. The APA has profoundly impacted his professional life, so he is pleased to be able to give back to the society in this way. He is also a past President of the International Association of Pancreatology where he was instrumental in organizing various national societies in pancreatology and the society journal. He was honored to receive the IAP’s Palade Award in 2013. Dr Saluja would like to thank the APA for honoring him with the Vay Liang and Frisca Go Award for Lifetime Achievement, which he accepts on behalf of his entire group. He would further like to express his gratitude to all the hardworking scientists in his laboratory, both past and present, who work tirelessly researching the pancreas and its diseases. In addition, he would like to thank Markus Lerch for his long friendship and collaboration. Of course, none of this would be possible without the consistent and never failing support of his wife (Manju), 2 sons (Varun and Anuj), and daughter-in-law (Prerna). He would like to dedicate this award to the individuals and families who suffer from pancreatic cancer and pancreatitis. It is for them that we strive daily to find a cure for this terrible disease. William Y. CHEY, MD, MSc, DScFigureDr William Y. Chey was born in 1930 and spent his formative years in a rural farming town in southeastern Korea. He received his MD from Seoul National University College of Medicine before serving in the Republic of Korea Army as a medical officer in the Korean War. After the war, he immigrated to the United States in 1954 and received postgraduate training in internal medicine and pathology at New York City Hospital, Mount Sinai Hospital in New York and at University of Pennsylvania Graduate School of Medicine Affiliated Hospitals in Philadelphia, Pa. He completed a fellowship in gastroenterology and hepatology at Medical University of New Jersey and Temple University Health Sciences Center. He received postdoctoral degrees, including master of medical science in gastroenterology and doctor of science in internal medicine from the University of Pennsylvania School of Medicine. He served as a member of the full-time academic faculty in the Division of Gastroenterology and the Department of Internal Medicine at Temple University Medical Center in Philadelphia, Pa, from 1960 to 1971. At the Temple University Medical Center, Dr Chey achieved the rank of associate professor of medicine and director of gastrointestinal research laboratory before moving to Rochester, New York, in 1971 where he became the founding director of the Isaac Gordon Center for Digestive Diseases and Nutrition at the Genesee Hospital and was appointed as professor of medicine at the University of Rochester Medical Center. Within a short time, the Isaac Gordon Center was recognized as the premiere clinical and research center for digestive diseases in upstate New York. In July 1992, he assumed a new post as director of the Division of Gastroenterology and Hepatology at the University of Rochester School of Medicine and Dentistry at the Strong Memorial Hospital and program director of the Gastroenterology Fellowship Training Program at the University of Rochester Medical Center. He became the founding director of the William B. and Sheila Konar Center for Digestive and Liver Diseases there in 1994. His diverse research interests have covered neurohormonal regulation of the digestive system; cancer of the gastrointestinal tract, pancreas, and liver; swallowing disorders; peptic ulcer disease; inflammatory bowel disease; gastrointestinal motility and functional bowel disorders; malabsorption syndromes; chronic liver diseases; and pancreatic diseases. Dr Chey has made a number of seminal observations relevant to exocrine pancreatic physiology. His team defined the importance of secretin as a circulating hormone and was the first to prove its critical role in pancreatic secretion of water and bicarbonate. In highly quoted articles published in Journal of Clinical Investigation, American Journal of Physiology, Gastroenterology, and Pancreas, Dr Chey's team was the first to report on secretin-releasing peptide. His group has also made key observations regarding the neurohormonal regulation of exocrine pancreatic function by CCK, pancreatic polypeptide, and PYY. In manuscripts published in Annals of Internal Medicine, Gastroenterology, and Annals of Surgery, his group was also the first to report the existence of a gastric acid hypersecretory syndrome resulting from a non–gastrin peptide. Dr Chey has devoted considerable effort in teaching as well as serving as a role model and mentor to generations of gastroenterologists. More than 100 physicians and scientists from the United States, Asia, Africa, and Europe received their internal medicine and/or gastroenterology training from Dr Chey. Many of these individuals hold leadership positions in their respective countries, including department chairs, deans, journal editors, and medical center chief executive officers. He has served as a visiting professor at many of the leading domestic and international university medical centers and as an invited speaker/lecturer at numerous national and international scientific meetings. He has served as a regular member of the NIH Surgery and Bioengineering Study Section and as a member of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee of the US government. He is an emeritus professor at Catholic University, College of Medicine, in Seoul, South Korea, and a visiting professor at Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing; Shanghai Medical University in Shanghai, China; Yonsei University College of Medicine and Korea University College of Medicine in Seoul; and Hallym University, College of Medicine, in Chuncheon, South Korea. He has served as an editorial board member of some of the leading scientific journals in gastroenterology. He has held memberships in the American Federation for Clinical Research, American Gastroenterological Association (AGA) (fellow), American College of Gastroenterology (fellow), American Physiological Society, American Society for Study of Liver Diseases, American Society for Gastrointestinal Endoscopy, American Physiological Society, American Neurogastroenterology and Motility Society, International Association of Pancreatology, American College of Acupuncture, and American Society of Acupuncture (past president). He had the honor of serving as the president of the APA in 1999. He is a recipient of the Distinguished Clinician Award, which is the highest honor bestowed on a clinical gastroenterologist for a lifetime of exemplary service by the AGA. He has also received the Mentor’s Research Award of the AGA and is a member of the AGA Legacy Society. At the annual meeting of the American College of Gastroenterology in October 2000, he received the Board of Governors Award for Best Clinical Research. After completing his tour of duty at the University of Rochester in 2000, Dr Chey established the Rochester Institute for Digestive Diseases and Sciences, a private institute that combined cutting-edge clinical science with the art of medicine to provide extraordinary clinical care to patients with gastrointestinal and liver diseases. At the age of 82 years, Dr Chey retired in 2012. He is now enjoying retirement with his wife Fan, 4 children, and 9 grandchildren in Rochester, New York. APA DISTINGUISHED SERVICE AWARD In 2011, the board of the APA established the APA Distinguished Service Award as a way to recognize those who help fulfill the APA mission to advance clinical and basic research for diseases of the pancreas while training the next generation of researchers who are devoted to finding a cure for these deadly diseases. The APA presented the first Distinguished Service Award in 2012 to Dr Edward D. Purich, founder of ChiRhoClin. His organization uses its resources to promote research through travel grants and other programs for young physicians. The 2013 recipient was Ms Agi Hirshberg, chief executive officer and founder of the Hirshberg Foundation for Pancreatic Cancer Research. She has supported our annual meeting, and her foundation has provided more than $5 million in seed grant funding for pancreatic cancer research.5,6 The 2014 recipient is Dr Stephen P. James, MD, director of the Division of Digestive Diseases and Nutrition of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). For the last decade, his leadership of the division is responsible for providing grants in support of pancreatic diseases for scientists throughout the United States and the world. Stephen P. James, MDFigureDr Stephen James is the director of the Division of Digestive Diseases and Nutrition of the NIDDK of NIH in Bethesda, Maryland. He was born in Columbus, Ohio, and was raised in Ohio, New Jersey, Texas, and Massachusetts. He graduated from Cornell University with a BA in chemistry, following which he received an MD degree at the Johns Hopkins University, where he completed subsequent residency training in internal medicine. This was followed by gastroenterology and hepatology fellowship training at the University of Maryland in Baltimore and at the Liver Unit of NIDDK. At the NIH, Dr James conducted research directed at understanding the human immune system and its role in both liver and alimentary diseases as well as immunodeficiency diseases, with a particular focus on the effector and regulatory functions of T cells in pathophysiology. This research was performed while working in the Metabolism Branch of the National Cancer Institute and, later, in the newly established Mucosal Immunity Section of the Laboratory of Clinical Investigation of the National Institute of Allergy and Infectious Diseases. He then moved to the University of Maryland School of Medicine in Baltimore as professor of medicine and head of the Division of Gastroenterology. His agenda there was diverse, including upgrading clinical services, initiating new research programs, developing new medical school curricula, and revamping the gastrointestinal fellowship program. Additional highlights included new research projects with the Center for Vaccine Development, opening a new liver transplantation program, planning for a new General Clinical Research Center funded by the NIH, and opening the new Baltimore VA Medical Center adjacent to university hospital. Dr James returned to the NIH to the extramural Division of Digestive Diseases and Nutrition, where he has been a director for the last 10 years. The division is responsible for providing grant support for scientists throughout the United States and the world who are engaged in basic, translational, and clinical research in digestive diseases, nutrition, and obesity. The program includes a diverse array of large and small grants, career development, and fellowship awards; digestive diseases and nutrition centers; and multicenter clinical trials. The division organizes meetings and workshops aimed at identifying new research opportunities and barriers. Dr James was the chair of the National Commission on Digestive Diseases, which released a comprehensive plan for research needs and opportunities in 2009. The division has developed multiple new programs on the basis of emerging technologies in genetics, stem cell biology, human microbiome, metabolomics, and high-throughput preclinical translation to name a few. To promote the NIDDK’s broad research mission, Dr James has developed many partnerships with professional and lay organizations as well as other agencies and departments of the federal government, including the Food and Drug Administration, Centers for Disease Control and Prevention, and USDA. He has been a long-standing scientific advisor to many organizations including the Crohn’s and Colitis Foundation of America, the Crohn’s and Colitis Foundation of Canada, the Broad Medical Research Program, the AGA, the National Association for Pediatric Gastroenterology, Hepatology, and Nutrition, and the American Association for the Study of Liver Diseases. Dr James is a current member of the advisory board of the Institute of Nutrition, Metabolism, and Diabetes of the Canadian Institutes of Health Research. Along with many leaders of the scientific community, he has worked closely with Mrs Jane Holt, copresident of the National Pancreas Foundation and a past member of the National Commission on Digestive Diseases and the NIDDK Advisory Committee, to accelerate and expand research in pancreatic diseases. The NIDDK has recently sponsored individual research workshops on pancreatitis, pancreatic cancer, and diabetes and, this year, on total pancreatectomy and auto-islet cell transplantation. Dr James is the author of more than 200 scientific publications, books, book chapters, editorials and commentaries, reviews, and educational courses. He is the recipient of a number of commendations, including the PHS Commendation Medal, the NIH Director’s Award, and the AGA Research Service Award. ACKNOWLEDGMENT The authors thank the recipients and Dr William Chey for their assistance in writing up the biography.