I. The genetically epilepsy-phone rat: An overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs
1986; Elsevier BV; Volume: 39; Issue: 9 Linguagem: Inglês
10.1016/0024-3205(86)90454-6
ISSN1879-0631
AutoresCharles E. Reigel, John W. Dailey, Phillip C. Jobe,
Tópico(s)RNA and protein synthesis mechanisms
ResumoThe Genetically Epilepsy-Prone Rat (GEPR) is rapidly gaining support as a model of epilepsy. In addition to a marked sensitivity to both sound-induced and hyperthermic seizures, GEPRs exhibit unusual sensitivity to a number of seizure-provoking modalities, including various forms of electrical and chemical stimulation. The existence of a moderate seizure colony (GEPR-3) and a severe seizure colony- (GEPR-9) allows pathophysiological studies of seizure susceptibility and severity. The consistency of seizures within each colony allows for comparison in seizures naive GEPRs and seizure experienced GEPRs. The consistent seizure responses of the GEPR are also ideal for the testing of anticonvulsant drugs. Further, the relative potencies of anti-convulsant drugs between the two colonies of GEPRs predict the clinical efficacies of traditional antiepileptic drugs and may be able to predict novel anticonvulsants.
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