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Studies of serum lipoprotein concentrations in children: A preliminary report

1974; Elsevier BV; Volume: 56; Issue: 1 Linguagem: Inglês

10.1016/0009-8981(74)90193-4

1873-3492

Gerald S. Berenson, P.S. Pargaonkar, S R Srinivasan, Edward R. Dalferes, B. Radhakrishnamurthy,

Adipokines, Inflammation, and Metabolic Diseases

Abstract Serum lipid studies were performed on 333 children, aged 3–16 years. These studies measured total cholesterol, triglycerides, α-lipoprotein cholesterol, β- plus pre-β-lipoprotein cholesterol, and the serum concentrations of β-,pre-β, and α-lipoproteins. Mean serum cholesterol (170 mg/100 ml) for children of 3–4 years was already as high as for young male adults 23–25 years (172 mg/100 ml), but cholesterol derived from a-lipoprotein constituted 48% of the total cholesterol in children and only 28% in young adults. From childhood through maturation and adulthood, a transition appears to occur in the patterns of the different classes of serum lipoproteins. Serum triglycerides in children (77 mg/100 ml) were slightly lower than in medical students (86 mg/ 100 ml), and their pre-β-lipoprotein concentrations (47 mg/100 ml) were about half those of the students (97 mg/100 ml). These studies emphasize that evaluation of lipid abnormalities in children requires specific study of serum lipoproteins in addition to observations of integral components, such as cholesterol, common to each of the lipoproteins.