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TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

2009; Elsevier BV; Volume: 216; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2009.08.013

1872-8421

Angela R. Kamer, Ronald G. Craig, Elizabeth Pirraglia, Ananda P. Dasanayake, Robert G. Norman, Robert J. Boylan, Andrea Nehorayoff, Lidia Glodzik, Mirosław Bryś, Mony J. de Leon,

Salivary Gland Disorders and Functions

The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-α and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-α and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-α classification of clinical AD and NL. This study shows that TNF-α and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis.