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Rhodium promoted isomerisation of allylic alkoxides: a new method for enolate anion formation

1999; Issue: 8 Linguagem: Inglês

10.1039/a901370i

2050-8255

Lewis Gazzard, William B. Motherwell, David A. Sandham,

Asymmetric Synthesis and Catalysis

Transition metal mediated isomerisation of allylic alkoxides is presented as a new method for enolate anion generation. The scope and limitations of enolate formation with the catalysts [Rh(dppe)(THF)2]+ClO4– and (Ph3P)3RhCl are explored and the synthetic potential of the methodology demonstrated in the stereoselective formation and reactions of certain ketone and aldehyde enolates.