Portal de Periódicos da CAPES

Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy

2011; Elsevier BV; Volume: 99; Issue: 2 Linguagem: Inglês

10.1016/j.radonc.2011.05.007

1879-0887

Robert Murray, George A. Tanteles, Jamie Mills, Angus Perry, Irene Peat, A. E. Osman, Stephen Chan, Kwok‐Leung Cheung, Prabir Chakraborti, Pamela Woodings, Julian Barwell, R.P. Symonds, Chris J. Talbot,

Carcinogens and Genotoxicity Assessment

Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy.