Portal de Periódicos da CAPES

GRANULOSA CELL TUMOR OF THE ADULT TESTIS. REPORT OF A CASE AND REVIEW OF THE LITERATURE

2006; Elsevier BV; Volume: 61; Issue: 1 Linguagem: Inglês

10.1590/s1807-59322006000100013

1980-5322

Marcelo Hisano, Frederico Mota Mascarenhas Souza, Denise Maria Avancini Costa Malheiros, Antônio Carlos Lima Pompeo, Antonio Marmo Lucón,

Urologic and reproductive health conditions

A 59-year-old man, referred to us with a 2-year historyof a painless growing mass in the left testis without pasthistory of trauma, infection, or lower urinary tract symp-toms. Physical exams revealed a normal right epididymisand testis, and a 13-cm mass and hydrocele in the left tes-tis, without hernia. Ultrasonography showed a 15 x 11 x12 cm mass with solid and cystic components and a largehydrocele. Serum levels of alpha-fetoprotein, beta-hCG,and LDH were within normal ranges. He underwent in-guinal surgical exploration of the left testis in October2000, when a large testicular mass was found. A radicalorchiectomy was performed, and the hydrocele fluid wasanalyzed. No frozen section biopsy was performed. His-topathological examination showed a 9-cm yellow tumor,with a small degenerated cystic area. Final analysis revealeda granulosa cell tumor with oval nuclei having a longitu-dinal nuclear groove (coffee bean appearance – Figure 1),focal invasion of the tunica albuginea and rete testis, nomitotic figures, and no invasion of surgical margins, sper-matic cord, or epididymis. Cytological analysis of the hy-drocele fluid was negative for tumor cells. Immunohisto-chemical tests were positive for vimentin, actin HFN 35,desmin, and cytokeratin AE-1/AE-3, but negative for epi-thelial membrane antigen. These findings strongly suggestthe diagnosis of a granulosa cell tumor.Follow-up was carried out with determinations of se-rum levels of alpha-fetoprotein, beta-hCG, and LDH, aswell as computerized tomography of the abdomen and chestx-ray every 6 months for 4 years, with no clinical recur-rence or exam abnormalities.Described for the first time in 1952,