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Biosynthesis of heme in leukemic leukocytes

1967; Wiley; Volume: 20; Issue: 7 Linguagem: Inglês

10.1002/1097-0142(196707)20

1097-0142

Thomas R. Walters, Frederick H. Welland, T. John Gribble, Herbert C. Schwartz,

Porphyrin and Phthalocyanine Chemistry

CancerVolume 20, Issue 7 p. 1117-1123 ArticleFree Access Biosynthesis of heme in leukemic leukocytes Thomas R. Walters MD, Thomas R. Walters MD Department of Pediatrics, University of Kansas School of Medicine, Kansas City, Kans.Search for more papers by this authorFrederick H. Welland MD, Corresponding Author Frederick H. Welland MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif., Formerly NIH Special Fellow (1F3CA22, 94301)Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif.===Search for more papers by this authorT. John Gribble MD, T. John Gribble MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif.,Search for more papers by this authorHerbert C. Schwartz MD, Herbert C. Schwartz MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif., John and Mary R. Markle Scholar in Academic Medicine.Search for more papers by this author Thomas R. Walters MD, Thomas R. Walters MD Department of Pediatrics, University of Kansas School of Medicine, Kansas City, Kans.Search for more papers by this authorFrederick H. Welland MD, Corresponding Author Frederick H. Welland MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif., Formerly NIH Special Fellow (1F3CA22, 94301)Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif.===Search for more papers by this authorT. John Gribble MD, T. John Gribble MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif.,Search for more papers by this authorHerbert C. Schwartz MD, Herbert C. Schwartz MD Departments of Pediatrics and Medicine, Stanford University School of Medicine, Palo Alto, Calif., John and Mary R. Markle Scholar in Academic Medicine.Search for more papers by this author First published: July 1967 https://doi.org/10.1002/1097-0142(196707)20:7 3.0.CO;2-ZCitations: 9 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The incorporation of 59Fe into heme and the synthesis of δ-aminolevulinic acid by leukocyte homogenates were studied. Whereas polymorphonudear peritoneal exudates from rabbits, as well as leukocytes from healthy adult volunteers and patients with chronic leukemia, lacked the capacity to incorporate radioiron into heme, immature leukemic cells from patients with acute leukemia possessed iron-incorporating activity. In addition these cells could utilize δ-aminolevulinic acid as substrate for heme synthesis. Delta-aminolevulinic acid synthetase activity could not be demonstrated in immature leukemic cells nor could they utilize glycine as substrate for heme synthesis. This work does not reveal whether the heme-synthesizing capacity in immature leukemic leukocytes is a function of this immaturity or of malignant transformation. Citing Literature Volume20, Issue7July 1967Pages 1117-1123 ReferencesRelatedInformation