Portal de Periódicos da CAPES

Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins

1987; Oxford University Press; Volume: 15; Issue: 7 Linguagem: Inglês

10.1093/nar/15.7.2945

1362-4962

Shinya Suzu, Yuko Sakai, Tatsuo Shioda, Hiroshi Shibuta,

Microbial infections and disease research

By analysing complementary DNA clones constructed from genomic RNA of bovine parainfluenza 3 virus (BPIV3), we determined the nucleotide sequence of the region containing the entire F and HN genes. Their deduced amino acid sequences showed about 80 % homologies with those of human parainfluenzs 3 virus (HPIV3), about 45 % with those of Sendai virus, and about 20 % with those of SV5 and Newcastle disease virus (NDV), indicating, together with the results described in the preceding paper on the NP, P, C and M proteins of BPIV3, that BPIV3, HPIV3 and Sendai virus constitute a paramyxovirus subgroup, and that BPIV3 and HPIV3 are very closely related. The F and HN proteins of all these viruses, including SV5 and NDV, however, were shown to have protein-specific structures as well as short but well-conserved amino acid sequences, suggesting that these structures and sequences are related to the activities of these glycoproteina.