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A targeted mutational landscape of angioimmunoblastic T-cell lymphoma

2013; Elsevier BV; Volume: 123; Issue: 9 Linguagem: Inglês

10.1182/blood-2013-10-531509

1528-0020

Oreofe O. Odejide, Oliver Weigert, Andrew A. Lane, Daniel Toscano, Matthew A. Lunning, Nadja Kopp, Sunhee S. Kim, Diederik van Bodegom, Sudha Bolla, Jonathan H. Schatz, Julie Teruya‐Feldstein, Ephraim P. Hochberg, Abner Louissaint, David M. Dorfman, Kristen E. Stevenson, Scott J. Rodig, Pier Paolo Piccaluga, Eric D. Jacobsen, Stefano Pileri, Nancy L. Harris, Simone Ferrero, Giorgio Inghirami, Steven M. Horwitz, David M. Weinstock,

Acute Myeloid Leukemia Research

Key Points AITL is characterized by high frequencies of overlapping mutations in epigenetic modifiers, including TET2, IDH2, and DNMT3A. Targetable mutations are present in a subset of cases.