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BIBTEX RIS

Preparation and antitubercular activity of lipophilic diamines and amino alcohols

2009; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 104; Issue: 5 Linguagem: Inglês

10.1590/s0074-02762009000500006

ISSN

1678-8060

Autores

Celso de Oliveira Rezende Júnior, Mireille Le Hyaric, Cristiane França da Costa, Taís Arthur Corrêa, Aline F. Taveira, Débora P. Araújo, Elaine F. C. Reis, Maria Cristina S. Lourenço, Felipe RC Vicente, Mauro V. de Almeida,

Tópico(s)

Tuberculosis Research and Epidemiology

Resumo

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 ¼g/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 ¼g/mL.

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