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Effect of chloroquine on the sulfhydryl group and the denaturation of bovine serum albumin

1964; Wiley; Volume: 7; Issue: 3 Linguagem: Inglês

10.1002/art.1780070302

1529-0131

Donald A. Gerber,

Blood disorders and treatments

Abstract Chloroquine diphosphate was demonstrated to be capable of blocking the sulfhydryl disulfide interchange reaction that ordinarily occurs during the denaturation of bovine serum albumin by either heat or urea. Chloroquine was also shown to inhibit the reduction of ferricyanide by cysteine, and to bind to certain sulfhydryl groups of human serum protein when present in concentrations found in patients taking the compound for rheumatoid arthritis.