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Assessment of the CASP4 fold recognition category

2001; Wiley; Volume: 45; Issue: S5 Linguagem: Inglês

10.1002/prot.10006

1097-0134

Manfred J. Sippl, Peter Lackner, Francisco S. Domingues, Andreas Prli, Rainer Malik, Antonina Andreeva, Markus Wiederstein,

Advanced Proteomics Techniques and Applications

Proteins: Structure, Function, and BioinformaticsVolume 45, Issue S5 p. 55-67 Fold Recognition: Assessment Assessment of the CASP4 fold recognition category Manfred J. Sippl, Corresponding Author Manfred J. Sippl sippl@came.sbg.ac.at Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, Austria ProCeryon Biosciences GmbH, Salzburg, AustriaCenter for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Jakob Haringer Straße 3, A 5020, Salzburg, Austria===Search for more papers by this authorPeter Lackner, Peter Lackner Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorFrancisco S. Domingues, Francisco S. Domingues Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorAndreas Prlić, Andreas Prlić Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorRainer Malik, Rainer Malik Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorAntonina Andreeva, Antonina Andreeva ProCeryon Biosciences GmbH, Salzburg, AustriaSearch for more papers by this authorMarkus Wiederstein, Markus Wiederstein ProCeryon Biosciences GmbH, Salzburg, AustriaSearch for more papers by this author Manfred J. Sippl, Corresponding Author Manfred J. Sippl sippl@came.sbg.ac.at Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, Austria ProCeryon Biosciences GmbH, Salzburg, AustriaCenter for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Jakob Haringer Straße 3, A 5020, Salzburg, Austria===Search for more papers by this authorPeter Lackner, Peter Lackner Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorFrancisco S. Domingues, Francisco S. Domingues Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorAndreas Prlić, Andreas Prlić Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorRainer Malik, Rainer Malik Center for Applied Molecular Engineering, Institute for Chemistry and Biochemistry, University of Salzburg, Salzburg, AustriaSearch for more papers by this authorAntonina Andreeva, Antonina Andreeva ProCeryon Biosciences GmbH, Salzburg, AustriaSearch for more papers by this authorMarkus Wiederstein, Markus Wiederstein ProCeryon Biosciences GmbH, Salzburg, AustriaSearch for more papers by this author First published: 28 January 2002 https://doi.org/10.1002/prot.10006Citations: 44Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We present the assessment of the CASP4 fold recognition category. The tasks we had to execute include the splitting of multidomain targets into single domains, the classification of target domains in terms of prediction categories, the numerical evaluation of predictions, the mapping of numerical scores to quality indices, the ranking of predictors, the selection of top-performing groups, and the analysis and critical discussion of the state of the art in this field. The 125 fold recognition groups were assessed by a total score that summarizes their performance over all targets and a quality score reflecting the average quality of the submitted models. Most of the top-performing groups achieved respectable results on both scores simultaneously. Several groups submitted models that were much closer to the respective target structures than any of the known folds in the Protein Data Bank. The CASP4 assessment included the automated servers of the parallel CAFASP experiment. For the total score, the highest rank achieved by a fully automated server is 12. Two thirds of the predictors have rather low scores. Proteins 2001;Suppl 5:55–67. © 2002 Wiley-Liss, Inc. Citing Literature Volume45, IssueS5Supplement: Fourth Meeting on the Critical Assessment of Techniques for Protein Structure Prediction2001Pages 55-67 RelatedInformation