Fluctuating Levels of Serum IgA in Individuals with Selective IgA Deficiency
1984; Wiley; Volume: 47; Issue: 1 Linguagem: Inglês
10.1111/j.1423-0410.1984.tb01562.x
ISSN1423-0410
AutoresCarol Laschinger, Dorothy K. Gauthier, Jean‐Paul Valet, D.H. Naylor,
Tópico(s)Blood groups and transfusion
ResumoAbstract. Monitoring of donors with selective IgA deficiency, i.e., with less than 0.5 mg IgA/1, led to the observation that serum IgA levels were not constant. Small but significant fluctuations in IgA levels were noted (coefficient of variance: 143%) which were greater than the variability inherent in the testing methodology (coefficient of variance: 10%). These fluctuations created difficulties in terms of defining IgA‐deficient blood products and had implications with respect to the mechanisms involved in IgA deficiency. With respect to supplying IgA‐deficient blood products, in our experience a cutoff level of 0.5 mg/1 should be the maximum permissible IgA concentration in order to ensure that no adverse reactions occur in individuals with class‐specific anti‐IgA.
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