Animals as sentinels of human health hazards of environmental chemicals.
1999; National Institute of Environmental Health Sciences; Volume: 107; Issue: 4 Linguagem: Inglês
10.1289/ehp.99107309
ISSN1552-9924
AutoresWilliam H. van der Schalie, Henry S. Gardner, John A. Bantle, C.T. De Rosa, Rick A. Finch, Jiří Reif, Roy Reuter, Lorraine C. Backer, Joanna Burger, Leroy C. Folmar, William S. Stokes,
Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
ResumoResearch ArticleOpen AccessAnimals as sentinels of human health hazards of environmental chemicals. W H van der Schalie, H S Gardner Jr, J A Bantle, C T De Rosa, R A Finch, J S Reif, R H Reuter, L C Backer, J Burger, L C Folmar, and W S Stokes W H van der Schalie U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , H S Gardner Jr U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , J A Bantle U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , C T De Rosa U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , R A Finch U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , J S Reif U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , R H Reuter U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , L C Backer U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , J Burger U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , L C Folmar U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. , and W S Stokes U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA. Published:1 April 1999https://doi.org/10.1289/ehp.99107309Cited by:79AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail AbstractA workshop titled "Using Sentinel Species Data to Address the Potential Human Health Effects of Chemicals in the Environment," sponsored by the U.S. Army Center for Environmental Health Research, the National Center for Environmental Assessment of the EPA, and the Agency for Toxic Substances and Disease Registry, was held to consider the use of sentinel and surrogate animal species data for evaluating the potential human health effects of chemicals in the environment. The workshop took a broad view of the sentinel species concept, and included mammalian and nonmammalian species, companion animals, food animals, fish, amphibians, and other wildlife. Sentinel species data included observations of wild animals in field situations as well as experimental animal data. Workshop participants identified potential applications for sentinel species data derived from monitoring programs or serendipitous observations and explored the potential use of such information in human health hazard and risk assessments and for evaluating causes or mechanisms of effect. Although it is unlikely that sentinel species data will be used as the sole determinative factor in evaluating human health concerns, such data can be useful as for additional weight of evidence in a risk assessment, for providing early warning of situations requiring further study, or for monitoring the course of remedial activities. Attention was given to the factors impeding the application of sentinel species approaches and their acceptance in the scientific and regulatory communities. Workshop participants identified a number of critical research needs and opportunities for interagency collaboration that could help advance the use of sentinel species approaches.FiguresReferencesRelatedDetailsCited By Roderick H, Urwin P and Atkinson H (2017) Rational design of biosafe crop resistance to a range of nematodes using RNA interference, Plant Biotechnology Journal, 10.1111/pbi.12792, 16:2, (520-529), Online publication date: 1-Feb-2018. Kumar A, Divoll T, Ganguli P, Trama F and Lamborg C (2018) Presence of artisanal gold mining predicts mercury bioaccumulation in five genera of bats (Chiroptera), Environmental Pollution, 10.1016/j.envpol.2018.01.109, 236, (862-870), Online publication date: 1-May-2018. 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