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Nanoparticles in Biological Systems

2011; Wiley; Volume: 50; Issue: 6 Linguagem: Inglês

10.1002/anie.200906684

1521-3773

Wendelin J. Stark,

Graphene and Nanomaterials Applications

Abstract Understanding the behavior of nanoparticles in biological systems opens up new directions for medical treatments and is essential for the development of safe nanotechnology. This Review discusses molecules and nanoparticles when in contact with cells or whole organisms, with a focus on inorganic materials. The interaction of particles with biology unravels a series of new mechanisms not found for molecules: altered biodistribution, chemically reactive interfaces, and the combination of solid‐state properties and mobility. Externally guided movement of medicaments by using functional nanomagnets brings mechanics into drug design. In subsequent sections, the role of inertness and bioaccumulation is discussed in regard to the long‐term safety of nanoparticles.