Histology and ultrastructure of an oncocytic adenoma of the human pituitary
1973; Wiley; Volume: 31; Issue: 5 Linguagem: Inglês
10.1002/1097-0142(197305)31
ISSN1097-0142
AutoresAlex M. Landolt, Ulrich W. Oswald,
Tópico(s)Head and Neck Surgical Oncology
ResumoA male patient was operated upon at the age of 33 and again at 46 years because of a recurrent pituitary tumor. He received a course of radiation therapy after the first operation. He showed only minimal endocrinologic deficit on both occasions. The initial symptom was visual difficulty. The light microscopy examination of the tumor suggested an oncocytoma in both instances. This diagnosis was established by electron microscopy by the demonstration of an abnormal accumulation of altered mitochondria in the tumor cells with concomitant reduction of other cell organelles, features characteristic for oncocytic cells. Secretory granules were extremely rare. This appears to be the first case of pituitary oncocytic adenoma with ultra-structural proof of the nature of the tumor.
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