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Cerebrovascular reactivity mapping for brain tumor presurgical planning

2011; Baishideng Publishing Group; Volume: 2; Issue: 7 Linguagem: Inglês

10.5306/wjco.v2.i7.289

2218-4333

Domenico Zacà, Jun Hua, Jay J. Pillai,

Medical Imaging Techniques and Applications

This article provides a review of Blood Oxygen Level Dependent functional magnetic resonance imaging (BOLD f�RI) applications for presurgical mapping in patients with brain tumors who are being considered for lesion resection.Initially, the physical principle of the BOLD effect is discussed, followed by a general overview of the aims of presurgical planning.Subsequently, a review of sensorimotor, language and visual paradigms that are typically utilized in clinical f�RI is provided, followed by a brief description of studies demonstrating the clinical impact of preoperative BOLD f�RI.After this thorough introduction to presurgical f�RI, a detailed explanation of the phenomenon of neurovascular uncoupling (NVU), a major limitation of f�RI, is provided, followed by a discussion of the different approaches taken for BOLD cerebrovascular reactivity (CVR) mapping, which is an effective method of detecting NVU.We then include one clinical case which demonstrates the value of CVR mapping in clinical preoperative f�RI interpretation.The paper then concludes with a brief review of applications of CVR mapping other than for presurgical mapping.