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Human Anaplasmosis and Anaplasma ovis Variant

2010; Centers for Disease Control and Prevention; Volume: 16; Issue: 6 Linguagem: Inglês

10.3201/eid1606.090175

1080-6059

Dimosthenis Chochlakis, Ioannis Ioannou, Yannis Tselentis, Anna Psaroulaki,

Mosquito-borne diseases and control

Anaplasmosis is a disease caused by bacteria of the genus Anaplasma.A. marginale, A. centrale, A. phagocytophilum, A. ovis, A. bovis, and A. platys are obligate intracellular bacteria that infect vertebrate and invertebrate host cells.A. ovis, which is transmitted primarily by Rhipicephalus bursa ticks, is an intraerythrocytic rickettsial pathogen of sheep, goats, and wild ruminants (1).Anaplasma spp.infections in humans have been reported in Cyprus (2,3).We report infection of a human with a strain of Anaplasma sp.other than A. phagocytophilum, which was detected by PCR amplifi cation of anaplasmatic 16S rRNA, major surface protein 4 (msp4), and heat shock protein 60 (groEL) genes.A 27-year-old woman was admitted to the pathology clinic of a hospital in Famagusta, Cyprus on May 14, 2007, with an 11-day history of fever (<39.5°C) after a tick bite.Before admission, the patient was treated with cefi xime (400 mg/d for 3 days) and cefradine (2 g/d for 2 days) without abatement of the fever.Physical examination showed hepatosplenomegaly and an enlarged lymph node.Initial laboratory examinations showed moderate anemia (hemoglobin 11.5 g/dL), thrombocytopenia (95,000 thrombocytes/mm 3 ), increased levels of transaminases (aspartate aminotransferase 178 U/L, alanine aminotransferase 313 U/L, γ-glutamyl transferase 79 U/L, lactate dehydrogenase 698 U/L), an increased level of C-reactive protein (10.4 mg/L), and an increased erythrocyte sedimentation rate (80 mm/h).Blood samples were obtained from the patient at the time of admission and 7 days and 3 months later.Results of blood and urine cultures were negative for bac-