Ergosterol biosynthesis and its inhibition by fenpropimorph in Fusarium species
1992; Elsevier BV; Volume: 31; Issue: 4 Linguagem: Inglês
10.1016/0031-9422(92)80265-g
ISSN1873-3700
AutoresDanièle Debieu, Claude Gall, Michel Gredt, Jocelyne J. Bach, Christian Malosse, Pierre Leroux,
Tópico(s)Plant Reproductive Biology
ResumoIn the mycelium of all the Fusarium species studied, the major sterol was ergosterol in the absence of fenpropimorph. In the presence of this fungicide fenpropimorph-sensitive strains, with the exception of F. nivale, accumulated mainly Δ8,14-sterols and tolerant ones accumulated either both Δ8,14- and Δ8-sterols or only Δ8-sterols. This seemed to indicate that fenpropimorph toxicity was related to sterol Δ14-reductase sensitivity. In F. nivale, which was highly sensitive to fenpropimorph, the accumulation of only Δ8-sterols indicated that the main target enzyme was sterol Δ8→Δ7-isomerase. In addition to Δ8,14-and Δ8-sterols, squalene was accumulated in very high amounts in several strains; the level of squalene accumulation did not seem to be correlated with fenpropimorph sensitivity.
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