Fatal overdose with citalopram?
1996; Elsevier BV; Volume: 348; Issue: 9038 Linguagem: Inglês
10.1016/s0140-6736(05)65441-4
ISSN1474-547X
AutoresFabrice Brion, N Brion, Michel Durigon,
Tópico(s)Schizophrenia research and treatment
Resumoöström and colleagues (Aug 3, p 339) 1 Öström M Eriksson A Thorson J Spigset O Fatal overdose with citalopram. Lancet. 1996; 348: 339-340 Summary Full Text Full Text PDF PubMed Scopus (114) Google Scholar report on six suicides in which overdose with citalopram was found. Selective serotonin-reuptake inhibitors (SSRI) are increasingly used in clinical practice and, as these workers rightly emphasise, are less toxic than tricyclic antidepressants. In the six reported deaths, citalopram concentrations were high and didesmethylcitalopram concentrations were low. Concentrations of other drugs were very low and could not be implicated. There have been reports of non-fatal citalopram intoxication at high doses. 2 Dencker SJ Høpfner Petersen HE Side-effect profile of citalopram and reference antidepressants in depression. Presented at XXII Nordiske psykiater-kongres, Reykjavik. 1989; : 31-42 Google Scholar , 3 Pedersen OL Kragh-Sørensen P Bjerre M Fredricson Overø K Gram LF Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect-a phase II study. Psychopharmacology. 1982; 77: 199-204 Crossref PubMed Scopus (60) Google Scholar
Referência(s)