Synthesis and Hemocompatibilities of New Segmented Polyurethanes and Poly(urethane urea)s with Poly(butadiene) and Phosphatidylcholine Analogues in the Main Chains and Long-Chain Alkyl Groups in the Side Chains
1997; American Chemical Society; Volume: 9; Issue: 7 Linguagem: Inglês
10.1021/cm960615o
ISSN1520-5002
AutoresYujun Li, Naotoshi Nakamura, Yanfeng Wang, Makoto Kodama, Tadao Nakaya,
Tópico(s)Flame retardant materials and properties
ResumoThree new phospholipid diols, bis[2-(2-hydroxyethyldimethylammonio)ethyl]diethylene octadecylamine diphosphate (BDODP), bis[2-(2-hydroxyethyldimethylammonio)ethyl]diethylene hexadecylamine diphosphate (BDHDP), and bis[2-(2-hydroxyethyldimethylammonio)ethyl]diethylene dodecylamine diphosphate (BDDDP), together with 1,4-butanediol (BD) or ethylenediamine (ED) as chain extender were further incorporated into the prepolymer of poly(butadiene) glycol (PBD) and 4,4'-methylenediphenyl diisocyanate (MDI). The bulk and surface characteristics of the resulting phospholipid segmented polyurethanes (SPUs) and segmented poly(urethane urea)s (SPUUs) were investigated by infrared (IR), gel permeation chromatography (GPC), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA), and contact angle measurements. The mechanical properties were investigated by dynamic viscoelasticity. The hemocompatibilities of the new polymers were evaluated by platelet-rich plasma (PRP) contact studies and viewed by scanning electron microscopy (SEM) using medical BioSpan as a reference. It was found that the new polymers possessed relatively hydrophobic surfaces revealed by contact angle measurements. Moreover, the new materials have good surfaces in terms of platelet adhesion and that the morphology of adhered platelets undergoes a relatively low degree of variation.
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