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The Ca2+/Mn2+ pumps in the Golgi apparatus

2004; Elsevier BV; Volume: 1742; Issue: 1-3 Linguagem: Inglês

10.1016/j.bbamcr.2004.08.018

1879-2596

Kurt Van Baelen, Leonard Dode, Jo Vanoevelen, Geert Callewaert, Humbert De Smedt, Ludwig Missiaen, Jan B. Parys, Luc Raeymaekers, Frank Wuytack,

Cellular transport and secretion

Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-sensitive intracellular Ca(2+) store. Besides Ca(2+)-release channels and Ca(2+)-binding proteins, the Golgi complex contains Ca(2+)-uptake mechanisms consisting of the well-known sarco/endoplasmic reticulum Ca(2+)-transport ATPases (SERCA) and the much less characterized secretory-pathway Ca(2+)-transport ATPases (SPCA). SPCA supplies the Golgi compartments and, possibly, the more distal compartments of the secretory pathway with both Ca(2+) and Mn(2+) and, therefore, plays an important role in the cytosolic and intra-Golgi Ca(2+) and Mn(2+) homeostasis. Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed.