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Prevalence and significance of isotypes of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

2008; BMJ; Volume: 67; Issue: 7 Linguagem: Inglês

10.1136/ard.2007.084855

1468-2060

Reema Syed, Brooke Gilliam, Terry L. Moore,

Systemic Lupus Erythematosus Research

Several studies have evaluated the potential role for IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies in juvenile idiopathic arthritis (JIA) concerning diagnosis and disease outcome.1–6 Unlike rheumatoid arthritis (RA),7 8 no study in JIA has evaluated the distribution of anti-CCP antibody isotypes and assessed their significance in the disease process. We assessed anti-CCP antibody isotype distribution in 72 consecutive patients with JIA (59 female and 13 male), including 14 with IgM RF-positive polyarthritis, 24 with IgM rheumatoid factor (RF)-negative polyarthritis, 21 with oligoarthritis, 11 with systemic-onset arthritis, and 2 with psoriatic arthritis. The mean (SD) age was 12.1 (5.8) years and mean disease duration was 4.8 (4.5) years. The levels of anti-CCP antibody isotypes were measured …