Hemolytic Anemia in Native Valve Infective Endocarditis
1999; Japanese Circulation Society; Volume: 63; Issue: 5 Linguagem: Inglês
10.1253/jcj.63.400
ISSN1347-4839
AutoresHsuan‐Li Huang, Fun‐Chung Lin, Kuo‐Chun Hung, Po‐Nan Wang, Delon Wu,
Tópico(s)Cardiac Valve Diseases and Treatments
ResumoHemolytic anemia is a rare manifestation of infective endocarditis. A 19-year-old man with a small ventricular septal defect developed right-sided infective endocarditis with huge vegetations involving the tricuspid valve, the ventricular septal defect, and the pulmonary valve. Intravascular hemolysis was suggested by the presence of numerous fragmented erythrocytes, giant platelets and polychromasia of the red blood cells. The direct Coombs test was positive, and there were spherocytes and splenomegaly, findings that suggested an immune-mediated mechanism also played a role in the hemolysis. The hematological picture persisted despite antibiotic therapy and recovered only after surgical removal of the vegetations, tricuspid and pulmonary valvectomy, and patch closure of the ventricular septal defect. (Jpn Circ J 1999; 63: 400 - 403)
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