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Surgical resection in disseminated testicular cancer following chemotherapeutic cytoreduction

1981; Wiley; Volume: 48; Issue: 4 Linguagem: Inglês

10.1002/1097-0142(19810815)48

1097-0142

Lawrence H. Einhorn, Stephen D. Williams, Isidore Mandelbaum, John P. Donohue,

Urologic and reproductive health conditions

CancerVolume 48, Issue 4 p. 904-908 ArticleFree Access Surgical resection in disseminated testicular cancer following chemotherapeutic cytoreduction† Lawrence H. Einhorn MD, Corresponding Author Lawrence H. Einhorn MD Departments of Medicine, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, Indiana American Cancer Society Clinical Professor of Oncology.Indiana University Medical Center: 1100 West Michigan Emerson Hall 435; Indianapolis, IN 46223===Search for more papers by this authorStephen D. Williams MD, Stephen D. Williams MD Departments of Medicine, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this authorIsidore Mandelbaum, Isidore Mandelbaum Departments of Thoracic Surgery, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this authorJohn P. Donohue MD, John P. Donohue MD Departments of Urology, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this author Lawrence H. Einhorn MD, Corresponding Author Lawrence H. Einhorn MD Departments of Medicine, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, Indiana American Cancer Society Clinical Professor of Oncology.Indiana University Medical Center: 1100 West Michigan Emerson Hall 435; Indianapolis, IN 46223===Search for more papers by this authorStephen D. Williams MD, Stephen D. Williams MD Departments of Medicine, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this authorIsidore Mandelbaum, Isidore Mandelbaum Departments of Thoracic Surgery, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this authorJohn P. Donohue MD, John P. Donohue MD Departments of Urology, Indiana University Medical Center and Veteran's Administration Medical Center, Indianapolis, IndianaSearch for more papers by this author First published: 15 August 1981 https://doi.org/10.1002/1097-0142(19810815)48:4 3.0.CO;2-OCitations: 169 † Presented in part at the American Association Cancer Research, San Diego, California, 1980. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Platinum combination chemotherapy will regularly produce a 70% complete response rate in testicular cancer. Many patients failing to achieve complete remission can still be rendered disease-free with surgical resection of residual localized disease. Twenty-one patients underwent resection for residual pulmonary lesions and 41 underwent lymphadenectomy for persistent retroperitoneal disease. There were no characteristic radiographic findings for fibrous tissue versus mature teratoma versus carcinoma. Although elevated HCG or AFP levels indicated the presence of carcinoma, negative HCG and AFP did not rule out such a diagnosis as 12 of 22 resected carcinoma patients were seronegative. Of 35 patients, 31 (89%) with fibrous tissue or mature teratomas and all four patients with immature teratomas have been continuously free of disease with a minimal postoperative follow-up time of six months. However, only two of 22 patients with resected carcinomas have been continuously disease-free. Postoperative chemotherapy for mature teratoma or fibrous tissue is probably not necessary. However, we feel that further aggressive chemotherapy is needed in the resected carcinoma patient with at least two courses of platinum combination chemotherapy. Surgical resection of residual disease following chemotherapy-induced cytoreduction with platinum combination chemotherapy may be therapeutic in some cases and helps to define the optimal subsequent treatment strategy. Citing Literature Volume48, Issue415 August 1981Pages 904-908 ReferencesRelatedInformation