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STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

2013; Elsevier BV; Volume: 122; Issue: 14 Linguagem: Inglês

10.1182/blood-2013-04-494930

1528-0020

Andrés Jerez, Michael J. Clemente, Hideki Makishima, Hanna Rajala, Inés Gómez‐Seguí, Thomas L. Olson, Kathy L. McGraw, Bartlomiej Przychodzen, Austin Kulasekararaj, Manuel Afable, Holleh Husseinzadeh, Naoko Hosono, Francis LeBlanc, Sonja Lagström, Dan Zhang, Pekka Ellonen, André Tichelli, C Nissen, Alan Lichtin, Aleksandra Wodnar‐Filipowicz, Ghulam J. Mufti, Alan F. List, Satu Mustjoki, Thomas P. Loughran, Jaroslaw P. Maciejewski,

Immune Cell Function and Interaction

Key Points STAT3+ T cells are found not only in detected concomitant LGL-BMFs, but in cases in which an LGL expansion was not suspected. Transformation via acquisition of a somatic mutation in T cells may be a mechanism of immune, mainly hypoplastic, bone marrow failure.