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Knitting complex weaves with DNA origami

2010; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês

10.1016/j.sbi.2010.03.009

1879-033X

William M. Shih, Chenxiang Lin,

Bacteriophages and microbial interactions

The past three decades have witnessed steady growth in our ability to harness DNA branched junctions as building blocks for programmable self-assembly of diverse supramolecular architectures. The DNA-origami method, which exploits the availability of long DNA sequences to template sophisticated nanostructures, has played a major role in extending this trend through the past few years. Today, two-dimensional and three-dimensional custom-shaped nanostructures comparable in mass to a small virus can be designed, assembled, and characterized with a prototyping cycle on the order of a couple of weeks.