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Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice

2008; Elsevier BV; Volume: 79; Issue: 7-8 Linguagem: Inglês

10.1016/j.fitote.2008.06.002

1873-6971

Carolina S.L. Franca, Fábia S. Menezes, L.C.B. Costa, Edenilson dos Santos Niculau, Péricles Barreto Alves, José Eduardo Brasil Pereira Pinto, Rosilene M. Marçal,

Psidium guajava Extracts and Applications

Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg; p.o.), the essential oil significantly reduced intestinal transit (P < 0.05) in the charcoal meal test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain.