Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol
2009; Dove Medical Press; Linguagem: Inglês
10.2147/tcrm.s5583
ISSN1178-203X
AutoresDavid A. Lubarsky, Eric A. Harris, Keith Candiotti,
Tópico(s)Intensive Care Unit Cognitive Disorders
ResumoFospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate.Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol.Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug's administration.Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.
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