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Peripheral neuropathy in osteosclerotic myeloma: Clinical and electrodiagnostic improvement with chemotherapy

1984; Wiley; Volume: 7; Issue: 2 Linguagem: Inglês

10.1002/mus.880070209

1097-4598

P. D. Donofrio, James W. Albers, H. S. Greenberg, Barry Mitchell,

Peripheral Neuropathies and Disorders

Abstract A patient with a severe remote‐effect polyneuropathy and other paraneoplastic features of osteosclerotic myeloma improved dramatically with melphalan and prednisone treatment. Serial electrodiagnostic studies provided an objective means of following the response to therapy and documented the improvement. We believe this represents the first reported patient with multifocal osteosclerotic myeloma and a myelomatous polyneuropathy responding to melphalan and prednisone.