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Chromones from the Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora mucronata

2009; American Chemical Society; Volume: 72; Issue: 4 Linguagem: Inglês

10.1021/np800748u

1520-6025

Jing Xu, Julia Kjer, Jandirk Sendker, Victor Wray, Huashi Guan, RuAngelie Edrada‐Ebel, Wenhan Lin, Jun Wu, Peter Proksch,

Marine Sponges and Natural Products

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.