TRANSFORMATION AND CHROMOSOME CHANGES INDUCED BY EPSTEIN-BARR VIRUS IN NORMAL HUMAN LEUKOCYTE CULTURES
1969; National Academy of Sciences; Volume: 63; Issue: 3 Linguagem: Inglês
10.1073/pnas.63.3.740
ISSN1091-6490
AutoresPaul J. Gerber, Jacqueline Whang‐Peng, James H. Monroe,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoThree separate attempts to establish long-term leukocyte cultures from the peripheral blood of a healthy adult who had no evidence of previous infection with Epstein-Barr virus were consistently unsuccessful. On the other hand, in vitro infection of buffy-coat cells of this donor with Epstein-Barr virus resulted in blastoid transformation of the lymphocytes and long-term growth potential. The transformation was accompanied by major chromosome changes. The significance of these findings in relation to lymphoproliferative diseases in man remains to be determined.
Referência(s)