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17-Hydroxylase: an evaluation of the present view of its catalytic role in steroidogenesis

2001; Elsevier BV; Volume: 78; Issue: 4 Linguagem: Inglês

10.1016/s0960-0760(01)00105-4

1879-1220

Seymour Lieberman, Patricia Warne,

Sexual Differentiation and Disorders

This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chamical reactions: pregnenolone→17-hydroxypregnenolone→dehydroepiandrosterone. This analysis suggests that the evidence supporting this view is not compelling enough to accept it unquestioningly. Different interpretations of the data can suggest other catalytic roles for 17-hydroxylase that are worthy of consideration. One such alternative is proposed.