Portal de Periódicos da CAPES

The role of SMARCB1/INI1 in the development of rhabdoid tumors

2009; Taylor & Francis; Volume: 8; Issue: 5 Linguagem: Inglês

10.4161/cbt.8.5.8019

1555-8576

Charles W.M. Roberts, Jaclyn A. Biegel,

Mechanisms of cancer metastasis

Rhabdoid tumors are especially lethal cancers that predominantly strike young children. The vast majority of rhabdoid tumors contain bi-allelic inactivating mutations in the SMARCB1 gene. Here we review clinicopathologic features of rhabdoid tumors and present recent insights into the mechanisms that drive oncogenesis in the absence of SMARCB1 function.