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Response to Comments on “A Bacterium That Can Grow Using Arsenic Instead of Phosphorus”

2011; American Association for the Advancement of Science; Volume: 332; Issue: 6034 Linguagem: Inglês

10.1126/science.1202098

1095-9203

Felisa Wolfe‐Simon, Jodi Switzer Blum, Thomas R. Kulp, Gwyneth W. Gordon, Shelley E. Hoeft, Jennifer Pett‐Ridge, John F. Stolz, Samuel M. Webb, Peter Weber, Paul Davies, Ariel D. Anbar, Ronald S. Oremland,

Porphyrin Metabolism and Disorders

Concerns have been raised about our recent study suggesting that arsenic (As) substitutes for phosphorus in major biomolecules of a bacterium that tolerates extreme As concentrations. We welcome the opportunity to better explain our methods and results and to consider alternative interpretations. We maintain that our interpretation of As substitution, based on multiple congruent lines of evidence, is viable.