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Beneficial Effects of Resveratrol on Atherosclerosis

2008; Mary Ann Liebert, Inc.; Volume: 11; Issue: 4 Linguagem: Inglês

10.1089/jmf.2007.0091

1557-7600

Enguo Fan, Lijuan Zhang, Sha Jiang, Yuhua Bai,

Adipokines, Inflammation, and Metabolic Diseases

Atherosclerosis, a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries, is a most important contributor to cardiovascular diseases. Resveratrol is a naturally occurring phytopolyphenol compound and shows the ability to reduce the risk of cardiovascular diseases. In this review, beneficial effects of resveratrol on the initiation and progression of atherosclerosis, including regulation of vasodilator and vasoconstrictor production, inhibition of oxidative stress/reactive oxygen species generation, anti-inflammation, inhibition of modification of low-density lipoproteins, anti-platelet aggregation, and its abilities to impede progression and modulate complications of atherosclerosis, are discussed.