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Debromosceptrin, an Alkaloid from the Caribbean Sponge Agelas conifera

1998; American Chemical Society; Volume: 61; Issue: 10 Linguagem: Inglês

10.1021/np980129a

1520-6025

Xiaoyu Shen, Tony L. Perry, Chuck Dunbar, Michelle Kelly‐Borges, Mark T. Hamann,

Chemical synthesis and alkaloids

As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas conifera collected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1−3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.