An Enantiodivergent Synthesis of (+)- and (−)-Centrolobines by Asymmetric Esterification Catalyzed by ( R )-(+)- N -Methylbenzoguanidine (( R )-NMBG)

Artigo Revisado por pares

An Enantiodivergent Synthesis of (+)- and (−)-Centrolobines by Asymmetric Esterification Catalyzed by ( R )-(+)- N -Methylbenzoguanidine (( R )-NMBG)

2013; Wiley; Volume: 2; Issue: 11 Linguagem: Inglês

10.1002/ajoc.201300139

ISSN

2193-5815

Autores

Kenya Nakata, Tatsuya Tokumaru, Hidetoshi Iwamoto, Yutaka Nishigaichi, Isamu Shiina,

Tópico(s)

Axial and Atropisomeric Chirality Synthesis

Resumo

Seventh heaven: The enantiodivergent synthesis of (+)- and (−)-centrolobines was achieved in a total of seven steps by using an asymmetric esterification in the presence of catalytic (R)-(+)-N-methylbenzoguanidine as the key reaction.

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An Enantiodivergent Synthesis of (+)- and (−)-Centrolobines by Asymmetric Esterification Catalyzed by ( R )-(+)- N -Methylbenzoguanidine (( R )-NMBG)