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Analysis of Neuron-Specific Enolase and S100B as Biomarkers of Cognitive Decline Following Surgery in Older People

2012; Karger Publishers; Volume: 34; Issue: 5-6 Linguagem: Inglês

10.1159/000345538

1421-9824

Emma L. Jones, Nathan Gauge, Odd Bjarte Nilsen, David Lowery, Keith Wesnes, Eirini Katsaiti, James Arden, Derek Amoako, Nicholas Prophet, Balaji Purushothaman, David Green, Clive Ballard,

S100 Proteins and Annexins

Background/Aims: Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Methods: Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Results: Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. Conclusion: NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.