Upper limit for intestinal absorption of a dilute glucose solution in men at rest
1997; Lippincott Williams & Wilkins; Volume: 29; Issue: 4 Linguagem: Inglês
10.1097/00005768-199704000-00009
ISSN1530-0315
AutoresStanley M. Duchman, Alan J. Ryan, Harold P. Schedl, Robert W. Summers, Timothy Bleiler, C. V. Gisolfi,
Tópico(s)Electrolyte and hormonal disorders
ResumoWe studied gastric and intestinal function by gastric intubation/intestinal perfusion in six healthy male volunteers to evaluate optimal use of a 6% glucose-electrolyte (GES) solution. Gastric volume, residual volume, emptying rate, and secretion were measured for an initial 763 ± 19 ml gastric load of GES and at the beginning and end of four additional gastric loads (2.2 ml·kg-1; ≈180 ml) given at 10-min intervals. The relatively high gastric (713 ± 58 ml) and residual (507 ± 26 ml) volumes maintained a high gastric emptying rate (19.5 ± 1.4 ml·min-1). Composition of the GES emptied into the duodenum was also measured in this first experiment. In a second experiment, this modified solution was infused (triple lumen tube) into the duodenum at a rate equal to gastric emptying rate, or at 38 or 77% greater rates. Absorption of water(11.3-12.9 ml·h-1·cm-1) and glucose 4.3-5.6 mmol·h-1·cm-1) were similar at all perfusion rates during the second experiment. We conclude that duodenojejunal segmental absorption rates of water and glucose produced by a rapid, sustained gastric emptying rate cannot be increased by delivering a greater load of glucose and water by intestinal perfusion.
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