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BIBTEX RIS

Synthesis of Azaphilone-Based Chemical Libraries

2012; American Chemical Society; Volume: 14; Issue: 3 Linguagem: Inglês

10.1021/co300002x

ISSN

2156-8952

Autores

Mathieu Achard, Aaron B. Beeler, John A. Porco,

Tópico(s)

Advanced Synthetic Organic Chemistry

Resumo

The synthesis of azaphilone scaffolds that have been further diversified by cross coupling acylation and amine addition is reported. Methodology development also led to novel modifications including C5 acetoxylation and condensations producing isoquinolin-6(7H) structures. Overall, the library synthesis afforded three azaphilone sublibraries, including vinylogous pyridones which project diversity elements in four sectors of the azaphilone core.

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