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Clinicopathologic Features of Two Rare Cases of Mesenchymal Metastatic Tumors in the Pancreas

2006; Lippincott Williams & Wilkins; Volume: 33; Issue: 3 Linguagem: Inglês

10.1097/01.mpa.0000234075.53630.2f

1536-4828

Paschalis Chatzipantelis, Eleni Karvouni, Georgios Panagiotis Fragoulidis, Dionysios Voros, Agathi Pafiti,

Renal cell carcinoma treatment

Objectives: A clinicopathologic presentation of 2 unusual cases of metastatic mesenchymal neoplasms in the pancreas. Methods: The first case concerns a 26-year-old man with a history of intracranial mesenchymal chondrosarcoma (since the age of 17), 2 left lung operations, and 3 right thigh operations. Distal pancreatectomy and splenectomy was performed because of suspicious mass in the pancreas. The second case concerns a 66-year-old woman with a history of uterus leiomyosarcoma (10 years ago) with left axillary and right femoral metastases. She underwent distal pancreatectomy and splenectomy because of suspicious mass measuring 4 × 4 cm, in the pancreatic body. Results: In the first case, the pathological examination revealed a tumor measuring 3.8 × 3.5 cm and histologically compatible with mesenchymal chondrosarcoma, developing in a vessel lumen and invading into the pancreatic parenchyma. In the second case, the pathological examination showed metastatic leiomyosarcoma of high-grade malignancy. The incidence of metastatic pancreatic tumors has been reported to be only 1.6% to 3%. Most of these tumors were of epithelial origin, and the most common sites of the primary lesions were the lung, kidney, and gastrointestinal tract. Conclusions: The cases of metastatic uterus leiomyosarcoma and the metastatic intracranial chondrosarcoma are, to our knowledge, the first to be described.