Long-term endocrine sequelae after surgery, radiotherapy, and chemotherapy in children with medulloblastoma
1987; Wiley; Volume: 59; Issue: 4 Linguagem: Inglês
10.1002/1097-0142(19870215)59
ISSN1097-0142
AutoresTitania Pasqualini, Blanca Diez, Horacio M. Domené, María Eugenia Escobar, Laura Grueiro, Juan J. Heinrich, Alicia S. Martínez, S Iorcansky, Federico Sackmann‐Muriel, M Rivarola,
Tópico(s)Hypothalamic control of reproductive hormones
ResumoThirteen children with medulloblastoma, were studied after 2 to 62 months off radiotherapy and chemotherapy with methotrexate and BCNU. Ages at time of study ranged from 2.3 to 15.7 years. Eleven patients, followed for a mean of 22 months, showed a significant decrease of height score, whereas nine patients had deficient growth hormone (GH) response to provocative tests. Clinical pubertal progression was normal in all patients, and three of five girls with advanced pubertal development had menarche. No evidences of gonadotropin disturbances were found in five patients whereas seven had raised basal folliclestimulating hormone (FSH) level or FSH response to luteinizing hormone-releasing hormone (LH-RH). Abnormalities in thyrotrophin (TSH) secretion were found in 9 of 13 patients. This study shows that poor growth and GH deficiency were frequent in our patients. The high frequency of thyroid disturbances observed point out the need of evaluating thyroid function for adequate replacement therapy. Perhaps modification of adjuvant chemotherapy in the future can diminish drug-induced gonadal damage. Cancer 59:801-806, 1987.
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