Produção Nacional
Revisado por pares
Antinociceptive Effects of the Aqueous Extract of Brugmansia suaveolens Flowers in Mice
2006; SAGE Publishing; Volume: 8; Issue: 3 Linguagem: Inglês
10.1177/1099800406293984
ISSN1552-4175
AutoresAlexander Garcia Parker, Gianni Goulart Peraza, Janaína Sena, Eli Sinnott Silva, Maria Cristina Flores Soares, Marta Regina Cezar Vaz, Eliana Badiale‐Furlong, Ana Luíza Muccillo-Baisch,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoThe infusion of Brugmansia suaveolens, popularly known as trombeteira or cartucheira, has been used to treat pain in Brazil. The present study was conducted to test for its antinociceptive effects using the abdominal-writhing, formalin, tail-flick, and hot-plate tests in mice. The aqueous extract from B. suaveolens flowers administered intraperitoneally at doses of 100 and 300 mg/kg body weight significantly inhibited acetic acid-induced abdominal constrictions. An increase in hot-plate latency was also observed in animals receiving both doses (100 and 300 mg/kg). In the formalin test, both doses from the aqueous extract inhibited the first (0-5 min) and second phase (20-25 min). Tail-flick assays demonstrated that treatment of animals with plant extract induced attenuation of the response. These results suggest that the aqueous extract from B. suaveolens flowers produced antinociceptive effects, as demonstrated in the experimental models of nociception in mice. This supports popular medicinal uses of this plant as an analgesic.
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