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The Effects of Acute Exposure to Deoxynivalenol on Some Inflammatory Parameters in Miniature Pigs

2011; Japanese Society of Veterinary Science; Volume: 73; Issue: 5 Linguagem: Inglês

10.1292/jvms.10-0461

1347-7439

Osamu Mikami, Midori KUBO, Hideo Murata, Yoshihiro Muneta, Yasuyuki NAKAJIMA, Shigeru Miyazaki, Nobuhiko TANIMURA, Ken Katsuda,

Indoor Air Quality and Microbial Exposure

Seven miniature pigs were injected intravenously with deoxynivalenol (DON) at 1 mg/kg body weight; afterward, the number of leukocytes in peripheral blood, the luminol-dependent chemiluminescence of neutrophils, the serum or plasma concentration of cytokines and acute-phase proteins were evaluated to determine the effects of acute exposure to DON on inflammatory responses. White blood cell counts were transiently increased at 3, 6, and 12 hr post-injection (PI) due to the increased number of neutrophils. The luminol-dependent chemiluminescence value of neutrophils was significantly elevated at 24 hr PI, indicating the activation of the bactericidal function of neutrophils. Significant increases of interleukin (IL)-8 and tumor necrosis factor-α at 3 hr PI and IL-6 at 6 hr PI were detected in the serum. The concentration of haptoglobin and serum amyloid A was significantly increased at 24 hr PI. These results suggest that acute exposure to DON induced a temporary recruitment of neutrophils in the peripheral blood by IL-8 and subsequent activation of the bactericidal function, and a transient increase of proinflammatory cytokines and acute-phase proteins, indicating the immunomodulatory effects of DON in pigs.